Autori
Adimari, Gianfranco
Chiogna, Monica
Duc Khanh, To

Titolo
Estimation of the volume under the ROC surface inpresence of nonignorable verification bias
Periodico
Statistical methods & applications : Journal of the Italian Statistical Society
Anno: 2019 - Volume: 28 - Fascicolo: 4 - Pagina iniziale: 695 - Pagina finale: 722

The volume under the receiver operating characteristic surface (VUS) is useful formeasuring the overall accuracy of a diagnostic test when the possible disease statusbelongs to one of three ordered categories. In medical studies, the VUS of a new testis typically estimated through a sample of measurements obtained by some suitablesample of patients. However, in many cases, only a subset of such patients has thetrue disease status assessed by a gold standard test. In this paper, for a continuous-scale diagnostic test, we propose four estimators of the VUS which accommodatefor nonignorable missingness of the disease status. The estimators are based on aparametric model which jointly describes both the disease and the verification process.Identifiability of the model is discussed. Consistency and asymptotic normality ofthe proposed estimators are shown, and variance estimation is discussed. The finite-sample behavior is investigated by means of simulation experiments. An illustrationis provided



SICI: 1618-2510(2019)28:4<695:EOTVUT>2.0.ZU;2-3

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