Autori
Schmidt, René
Faldum, Andreas
Gerss, Joachim

Titolo
Adaptive designs with arbitrary dependence structure based on Fisher's combination test
Periodico
Statistical methods & applications : Journal of the Italian Statistical Society
Anno: 2015 - Volume: 24 - Fascicolo: 3 - Pagina iniziale: 427 - Pagina finale: 447

Adaptive designs were originally developed for independent and uniformly distributed ......-values. However, in general the type I error rate of a given adaptive design depends on the true dependence structure between the stage-wise ......-values. Since there are settings, where the ......-values of the stages might be dependent with even unknown dependence structure, it is of interest to consider the most adverse dependence structure maximizing the type I error rate of a given adaptive design (worst case). In this paper, we explicitly study the type I error rate in the worst case for adaptive designs without futility stop based on Fisher's combination test. Potential inflation of the type I error rate is studied if the dependence structure between the ......-values of the stages is not taken into account adequately. It turns out that considerable inflation of the type I error rate can occur. This emphasizes that the examination of the true dependence structure between the stage-wise ......-values and an adequate choice of the conditional error function is crucial when adaptive designs are used.



SICI: 1618-2510(2015)24:3<427:ADWADS>2.0.ZU;2-A

Esportazione dati in Refworks (solo per utenti abilitati)

Biblioteche ACNP che possiedono il periodico